As digital computing and communication becomes faster, cheaper and available in packages which are smaller and use less power, these capabilities are becoming embedded in many objects and structures in the physical environment. Cyber-physical systems (CPS) are physical and engineered systems whose operations are monitored, coordinated, controlled and integrated by such computing and communication. Broad deployment of cyber-physical systems is transforming how we interact with the physical world as profoundly as the world wide web transformed how we interact with one another, and harnessing their capabilities holds the possibility of enormous societal and economic impact. ICCPS is the premier single-track conference for reporting advances in all aspects of cyber-physical systems, including theory, tools, applications, systems, testbeds and field deployments. This year, the conference features two focus areas for submissions: one on CPS foundations (the traditional focus of ICCPS), and one on secure and resilient infrastructure CPS (the focus of the former HiCoNS conference). The entire program committee is eligible to review in both areas, but authors will be asked to specify one of the two areas during submission in order to aid with reviewer selection The CPS foundations (CPSF) area focuses on core science and technology for developing fundamental principles that underpin the integration of cyber and physical elements. Application domains include transportation, energy, water, agriculture, ecology, supply-chains, medical and assistive technology, sensor and social networks, and robotics. Among the relevant research areas are security, control, optimization, machine learning, game theory, mechanism design, mobile and cloud computing, model-based design, verification, data mining / analytics, signal processing, and human-in-the-loop shared or supervisory control. The secure and resilient infrastructure CPS (HiCoNS) area focuses on the confluence of cyber-security, privacy, and CPS that impacts the operation of critical infrastructures such as the smart grid, water distribution, transportation, healthcare, building automation, and process control. Of particular interest is foundational work that cuts across multiple application areas or advances the scientific understanding of underlying principles for the development of high confidence (secure, reliable, robust, and trustworthy) networked CPS. Beginning this year, this focus area of ICCPS replaces the High Confidence Networked Systems (HiCoNS) conference.