ICCPS 2018 will, for the first time, have two tracks: Theory and Applications. Authors will be required to select a track (see description below) when submitting papers. Please note that the program co-chairs may move a paper to a more appropriate track based on their judgment and suggestions from the program committee.  Each track will have its own program committee. The theory track focuses on the core science to develop fundamental principles that underpin the integration of cyber and physical elements. The applications track focuses on the development of technologies, tools, and architectures for building CPS systems, and on the design, implementation, and investigation of CPS applications. Application domains for both tracks include (but are not limited to): transportation, energy, water, agriculture, ecology, supply-chains, medical and assistive technology, sensor and social networks, and robotics. Among the relevant research areas are security, control, optimization, machine learning, game theory, mechanism design, mobile and cloud computing, model-based design, verification, data mining / analytics, signal processing, and human-in-the-loop shared or supervisory control. Papers on secure and resilient CPS infrastructure (the focus of the former HiCoNS conference) can either be submitted to the theory or to the applications track depending on the emphasis of the paper.