Electronic conferences on synthetic organic chemistry (ECSOC) are a series of conferences maintained through the internet since 1997, an original initiative by MDPI, and later consolidated with the contribution of the University of Santiago de Compostela (Spain). Nowadays it constitutes the first and oldest electronic conference in the world. It maintains its character of free participation, with contributions considered as preliminary reports on edge achievements, and registration as a distinctive standard of the world wide web open access character.