Fungal, algal and cyanobacterial toxins are naturally occurring food and water contaminants that adversely affect human and animal health. A multidisciplinary approach is critical in understanding, managing and mitigating their health and economic impacts. The 2015 Gordon Research Conference on Mycotoxins and Phycotoxins will provide a forum for academic, government and private sector scientists to exchange ideas on harnessing advances in biology, chemistry, ecology, plant pathology, epidemiology and risk assessment to address the problems associated with occurrence of these natural toxins. The goal of the conference is to bring together a wide range of outstanding senior scientists, young investigators and students to address the very practical task of ensuring the safety of food and water supplies. Interactions between junior and senior scientists will to contribute to the evolution of new strategies for dealing with the complex problems presented by naturally occurring toxins. The key focus of conference presentations will be vigorous discussions guided by discussion leaders recognized for their expertise in each particular area. Poster sessions will provide an opportunity for fertile cross-disciplinary interactions. The Gordon Research Seminar, immediately preceding the GRC, will be organized and conducted by graduate students and postdoctoral scientists from the many disciplines involved in advancing mycotoxin and phycotoxin research. Junior scientists will present their work in a formal, oral format and engage in discussion with their peers. The environment will be welcoming and collegial and will provide an unmatched opportunity for future researchers to interact with established scientists.