The 2015 GRC on High-Throughput Chemistry and Chemical Biology (HTCCB) will feature cutting edge talks bridging the disciplines of organic chemistry and chemical biology across a diverse range of topics. Invited speakers from both industry and academia will focus on the latest advances in synthetic methodology, reaction discovery, chemical biology, medicinal chemistry, library synthesis, and screening. An overarching theme of the meeting is the application of high-throughput experimentation to research problems in these areas. The HTCCB GRC will continue its tradition of excellent science in a relaxed atmosphere and will be held at Colby-Sawyer College in New London, NH. In accord with past meetings, the 2015 HTCCB GRC will continue a tradition of an environment where colleagues and friends gather and engage in informal discussion and exchange of ideas. In addition to talks, the afternoon poster sessions are an important part of the scientific and social exchange at the HTCCB GRC and all conferees are encouraged to present a poster. I am especially pleased to announce that the 4th Gordon Research Seminar (GRS) for our conference will be held the weekend prior to the GRC on June 13-14. The HTCCB GRS is being organized by Justin Rettenmaier (University of California, San Francisco) and Betsy Parkinson (University of Illinois at Urbana-Champaign) and will provide an opportunity for trainees to share science and interact with leading researchers in an intimate setting. Graduate students and post-docs are encouraged to apply to both the GRS and GRC. Along with the conference Vice-Chair, Andy Phillips (Broad Institute), I invite you to apply to what I hope to be an exciting and memorable meeting.