The 46th Annual Symposium on Optical Materials for High Power Lasers is the leading forum for the exchange of information on the physics/technology of materials for high-power/high-energy lasers. The series of conference proceedings has grown to be a comprehensive source of information on optics for lasers and includes topics on laser-induced damage mechanisms, materials and thin film preparation, durability, properties modeling, testing, and component fabrication. The Symposium will include both oral and poster presentations with no parallel sessions. This year, a seminal tutorial focused on the growth and characterization of amorphous thin films for interference coatings will replace our Sunday afternoon Round Table Discussion. Distinguished international researchers in the field of optics for high-power/high-energy lasers will present invited talks. Submissions are solicited for the four core technical sessions and the Mini-Symposium.