While software development has traditionally been more of an empirical art than an engineering discipline, this is slowly changing as software users demand from software engineers the same levels of system reliability and predictability that are achieved by engineers in other disciplines. The workshop focuses on theoretical and practical aspects of Object Management Group’s Model-Driven Architecture, Model-Driven Software Development, Domain-Specific Languages based on models, Model-Driven Engineering, Model transformation and code generation, models for real-time and embedded systems, Models for SOA and web service design, Models for software product lines, and other Model-Driven Innovations for Software Engineering. All these closely-linked fields including Model-Driven Domain Analysis and Model-Driven Software Development are advancing rapidly as practitioners and theoreticians work together to create new techniques and extend understanding of how and why existing methods work (and also why they sometimes fail).The present fourth edition of the Special session on Model Driven Innovations for Software Engineering (MDI4SE 2018) follows the traditions of previous events (Barcelona, Spain 2015, Rome, Italy 2016, and Porto, Portugal 2017). It aims to bring together academics, researchers and industrial partners to share innovative achievements and discuss on how to improve quality, reliability and effectiveness of IT products and services.