Affective Computing (AC) has become an emerging and important branch of artificial intelligence that focus on the study and development of algorithms, systems and devices that can recognize, interpret, process and respond to human emotions. The relationship between human emotions and health and wellbeing is an emerging topic. This interdisciplinary field spans computer science, psychology, mental health, psychiatry, cognitive science, biomedicine and healthcare. This workshop provides a forum for exchange and discussion on affective computing in biomedicine and healthcare research, such as emotion detection, human and machine interaction, mood tagging, emotion modelling, semantic representation, affective support and tutoring. The selected papers will be published in a journal special issue (to be confirmed).