Wuyishan metallogenic belt is located in the junction area of Fujian, Guangdong, Zhejiang and Jiangxi in the southeast coast, and it is one of the 16th significant metallogenic belts in China. A series of large deposits such as Zijinshan Cu-Au deposit, Makeng Fe deposit, Dapai Mn deposit and Lengshuikeng Ag-Pb-Zn deposit are located in the metallogenic belt, and this belt has a huge metallogenic potentiality. In this paper, based on the comprehensive collection and collation of predecessors' data, detailed geological and tunnel geological observation and comprehensive indoor research work, the era of lithogeny and metallogenesis was discussed, the sources of minerals and ore-forming fluid were analyzed, and then ore genesis are investigated, with the purpose of providing a science basis for the prospecting work of the same type polymetallic deposits in this metallogenic belt.