Aiming at the problems of uncertainty and fuzziness for railway emergency, a decision-making method of railway emergency based on cloud model and TOPSIS is proposed. Firstly, the qualitative and quantitative transformation of linguistic decision-making information is realized using the uncertainty transformation of cloud model, and the evaluation values of the group decision-making are aggregated into the attribute clouds through the weighted backward cloud generator. Secondly, the attribute weights are obtained using the combination weighting method of AHP and entropy weight method. Thirdly, the closeness coefficient of each alternative with respect to the ideal solution is calculated using the TOPSIS, and the ranking and optimization of emergency alternatives are realized. Finally, the effectiveness and feasibility of the proposed method are verified with an example.