14 / 2024-10-09 11:27:19

Extracellular vesicles promote the infection and pathogenicity of Japanese encephalitis virus

Reducing zoonotic diseases and minimizing environmental pollution and food safety issues caused by diseases is crucial for One Health.
Japanese encephalitis virus (JEV) is a multihost trans-species zoonotic pathogen that poses a serious threat to public health. It is mainly transmitted by mosquitoes, pigs are the amplified host, and humans are the terminal host. After infection with JEV, pigs mainly suffer from reproductive system diseases, and humans have significant neurological symptoms. Extracellular vesicles (EVs) have been known to play an important role in viral infection and pathogenicity, but their specific functions in JEV remain unknown. Therefore, this study intends to isolate and purify EVs derived from different species, and utilize EVs to systematically study its role and mechanisms in viral replication, immune escape, and cross—species transmission, with providing new theoretical basis and drug targets for the prevention, control and treatment of JE.