Vegetation, as an important component of the earth system, can affect climate by modifying the exchange of carbon, water, momentum, and energy between atmosphere and land. The climatic impact of vegetation throughout evolution history has been still unclear due to the lack of extensive and systematic simulations and record. Here, Community Earth System Model (CESM) version 1.2.2 and BIOME4 vegetation model are applied to systematically explore climatic effects from vegetation biophysical feedbacks under different paleogeographic patterns and climate states. A series of simulations with vegetation and without vegetation are conducted based on modern vegetation parameters from 410 million years ago (Ma) to pre-industrial (PI) period with a 10-million-year interval. First, the simulations reveal that the presence of vegetation contributes to global warming in all periods, with global mean surface temperature and land mean surface temperature increasing by 2-6℃ and 4-9℃, respectively. Global mean and land mean precipitation increased, accordingly. Second, the results show the distinct characteristics of spatial patterns of temperature and precipitation changes induced by vegetation in all periods. Finally, the results illustrate how geographic patterns and climate states regulate the climatic effects of vegetation, and highlight the dominate role of albedo and the important contribution of snow and sea ice in vegetation biophysical feedbacks. Such knowledge is very useful for understanding the ambiguity in previous studies and instructive for future studies involving vegetation changes.