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87 / 2024-10-20 23:07:41
H3K14ac facilitates the reinstallation of constitutive heterochromatin in Drosophila early embryos by engaging Eggless/SetDB1
SetDB1,Heterochromatin,H3K14ac
6）表观基因组与三维基因组（召集人：丁俊军）
摘要录用
陈雨薇 / 中南大学湘雅医院
袁凯 / 中南大学
Repetitive DNA sequences in the genome can cause problems for our cells. To protect the genome, cells turn off these repetitive sequences by placing them in inactive heterochromatic areas and adding repressive markers. However, we don’t know exactly how this is achieved during early embryonic development. Here, we found that the repetitive sequences are densely labeled with an active marker H3K14ac. This marker to our surprise attracts a protein called Eggless/SetDB1 to foster a repressive environment, turning off these repetitive sequences in early fruit fly embryos. Experimentally disrupting this process unleashes many repetitive DNA sequences and harms organismal viability. Our finding uncovers a mode to turn off repetitive sequences in the development of early embryos

 
重要日期

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    10月31日

    2024

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    11月03日

    2024

  • 11月03日 2024

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崖州湾国家实验室
华中农业大学
浙江大学
中国遗传学会
中国遗传学会三维基因组学专委会
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中国生物信息学基因组信息学专委会
中国遗传学会表观遗传分会
中国细胞生物学学会染色质生物学分会
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