To address the inadequacy of traditional supplementary cementitious materials (SCMs), limestone calcined clay cement (LC3) appears to be an excellent alternative. Both kaolinite clay and limestone are abundant worldwide, which ensures an adequate supply. The production of both materials consumes low amounts of energy, and the resulting CO2 emission is largely reduced compared to conventional cement clinkers. Extensive studies concerning the hydration mechanism and microstructural characteristics of LC3 and the macrostructural mechanical performance of LC3 concrete have been carried out in Shenzhen University. Various LC3 concrete types including natural aggregate concrete, recycled aggregate concrete, seawater sea sand concrete, engineered cementitious composites, and ultra-high performance concrete have been investigated. The flexural behaviors of LC3 (recycled) concrete beams reinforced by CFRP, steel or their hybrid were studied, and the bond behavior between LC3 concrete and CFRP/steel has been investigated. Besides, the stress-strain modelling of LC3 concrete has been performed, and the life cycle design and energy saving analysis of LC3 concrete structure has been conducted.