摘要详情
212 / 2024-07-15 14:44:56
Assessment of Intestinal Impact from Nonalcoholic Fatty Liver Disease (NAFLD) Using Hepatoenteric Fluorescence-Photoacoustic Dual-Mode Imaging
Nonalcoholic fatty liver disease,Gut-liver axis,Photoacoustic imaging,Fluorescence imaging
全文待审
Nonalcoholic fatty liver disease (NAFLD) has become a predominant etiology of chronic liver disease on a global scale. Recent research has elucidated a strong correlation between NAFLD and the gut-liver axis. This investigation aims to analyze the impact of high-fat diet (HFD) and methionine-choline deficient diet (MCD) induced NAFLD models on intestinal microvasculature and permeability. Utilizing photoacoustic microscopy, alterations in intestinal microvasculature were monitored at various stages of the NAFLD models. Additionally, fluorescence imaging was utilized to evaluate intestinal permeability and gut-liver circulation. Fluorescent immunostaining of ZO-1 and PV-1 was performed to validate the influence of NAFLD on the gut-vascular barrier. Findings suggest that NAFLD results in heightened intestinal inflammation and microvessel proliferation, accompanied by a marked elevation in intestinal permeability as the disease advances. The group subjected to MCD diet exhibited more pronounced alterations in intestinal inflammation and permeability, possibly attributable to early inflammatory reactions triggered by the MCD diet. Furthermore, NAFLD has been shown to induce injury to the epithelial cell layer of the gut mechanical barrier, decrease expression of tight junction proteins, and enhance permeability of the intestinal mucosal and vascular barriers. This research elucidates the impact of NAFLD on the intestinal milieu through the gut-liver axis, offering novel perspectives and treatment approaches for the prevention and treatment of NAFLD.
重要日期
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会议日期
09月08日
2024
至09月12日
2024
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09月15日 2024
初稿截稿日期
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09月15日 2024
注册截止日期
主办单位
ShenZhen University
联系方式
- Organizing Committee
- ic******@163.com
- +86********
历届会议
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2009年05月11日 中国 哈尔滨市
2009年纳米光子学国际会议
