摘要详情
187 / 2024-06-15 23:55:04
In Vivo Tumor-Catalyzed Photoacoustic Imaging of Cyclic Cascade Reactions Driven by Multi-Enzyme Active Mesoporous Nanozymes
nanoenzymes,oxidative stress,photoacoustic imaging
全文待审
Oxidative stress is closely related to the occurrence and development of a variety of diseases, and is an important target for diagnosis and treatment, but there is a lack of accurate in-situ detection tools. Here, we synthesized nano-enzymes (Au@mIrO2) with excellent POD, OXD, and CAT enzymatic activities via a spontaneous galvanic dissolution and template-Induced regrowth, and utilized three-dimensional (3D) multispectral photoacoustic (PA) molecular imaging to monitor the in vivo cascade of catalytic therapeutics based on the multi-enzyme-driven cyclic reaction platform. Au@mIrO2 targeted to the liver induces changes in oxyHb and deoxyHb content, which, in combination with the PA response of the nano-enzymes, allows for the simultaneous mapping of 3D PA signals of dynamic endogenous and exogenous molecules associated with the catalytic process, leading to real-time, non-invasive in situ visual monitoring of oxidative stress in the liver. In addition, due to the LSPR effect of Au NR in the NIR-Ⅱ, the enhanced PA imaging capability and photothermal and ROS generation can be achieved in the realization of PA imaging for navigated tumor therapy.
重要日期
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会议日期
09月08日
2024
至09月12日
2024
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09月15日 2024
初稿截稿日期
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09月15日 2024
注册截止日期
主办单位
ShenZhen University
联系方式
- Organizing Committee
- ic******@163.com
- +86********
历届会议
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2009年05月11日 中国 哈尔滨市
2009年纳米光子学国际会议
