173 / 2024-06-14 16:42:57

Fe3O4@mSiO2@Au core@shell@satellites nanoparticles for magnetic field-induced synergistic therapy of cancer

magnetoplasmonic nanoparticle, magnetic field-induced, photothermal therapy, cancer chemotherapy, photothermal conversion efficiency enhancement, target drug delivery

Combination of chemotherapy with photothermal therapy (PTT) has recently been emerging in cancer nanomedicine. Due to a synergy of chemotherapy and PTT, a nanoplatform that simultaneously delivers PTT and chemotherapeutics can allow for effective tumor targeting and significantly enhanced cancer treatment efficacy along with lower systemic toxicity associated with chemotherapy alone. At the same time, use of magnetic field (MF) along with magnetic drug nanocarrier can enhance the tumor targeting efficiency and accelerate the accumulation of drugs at tumor site. In this talk, a MF-induced, combinational (chemotherapy/photothermal therapy) cancer therapy using the synthesized magnetoplasmonic Fe₃O₄@mSiO₂@Au core@shell@satellites nanoparticles, which are loaded with a chemotherapy drug doxorubicin (DOX, is presented). In the absence of MF, Fe₃O₄@mSiO₂@Au-DOX core@shell@satellites NPs remains dispersed and colloidally stable in water; a negligible near infrared (NIR) absorption at ~800 nm is observed and no photothermal effect is produced under 808 nm laser irradiation. In contrast, under external MF, the formation of Fe₃O₄@mSiO₂@Au-DOX aggregates is observed, leading to a plasmon resonance coupling between Au NPs within aggregates, which increases the absorption in the NIR region at ~800 nm, allowing for an enhanced photothermal effect under 808 nm laser irradiation. Notably, the MF-induced Fe₃O₄@mSiO₂@Au-DOX NPs aggregates were determined to a strongly enhanced photothermal conversion efficiency (~67 %) compared to without the application of MF (~19 %). As a result, an enhanced photothermal effect was manifested by MF treated NPs dispersion under irradiation by 808 nm laser diode. A NPs-delivered, tumor targeted combination of the MF induced NIR PTT with DOX chemotherapeutic action was shown to result in the efficient killing of cancer cells in vitro and in vivo. Histological studies revealed a significant difference in the development and malignancy between tumors injected with Fe₃O₄@mSiO₂@Au-DOX NPs and treated by MF application and 808 nm laser irradiation and the with control tumor treatments. Based on the obtained results, a tumor treatment strategy can be proposed that integrates MF-induced PTT and MF-targeted drug delivery, reveal a great potential of magnetoplasmonic nanoplatform in the combination of photothermal therapy and chemotherapy for synergistic therapy of cancer with the help of MF.