Abstract: Introducing the advance information technology and deeply fusing the measurement and control system with information system are key points to realize the intelligence of the measurement and control system. Cyber physical system (CPS) is a multidimensional complex system which merged the computation, network and information service using 3C (computation, communication, control) technology. CPS can bring about the real-time sensing, dynamic controlling and information service by effectively integrating technologies. This system has a wide application foreground. This paper proposed the idea and frame structure of establishing the CPS measurement and control. Firstly, we investigate the concept, main functions and technologic characters. Then, we studied the systematic structure and primary means of controlling CPS. Finally, we discussed the main challenges in the investigation of CPS from heterogeneity condition integration, timeliness, security and so on.